Trump Executive Order Tracker | Akin Public Policy and Lobbying

Delivering Most-Favored-Nation Prescription Drug Pricing to American Patients (Trump EO Tracker)

May 14, 2025

Reading Time : 2 min
Trump Executive Order Tracker | Akin Public Policy and Lobbying

This order makes it the policy of the United States to have the most-favored-nation price for prescription drugs and biologics.

The order directs the Secretary of Commerce and the United States Trade Representative to take all necessary and appropriate action to ensure foreign countries are not engaged in any act, policy, or practice that may be unreasonable or discriminatory or that may impair United States national security and that results in American patients paying for a disproportionate amount of global pharmaceutical research and development.

The Secretary of Health and Human Services (Secretary) shall facilitate direct-to-consumer purchasing programs for pharmaceutical manufacturers that sell their products to American patients at the most-favored-nation price.

The order establishes Most-Favored Nation Pricing by requiring:

  1. Within 30 days of the date of this order, the Secretary shall, in coordination with the Assistant to the President for Domestic Policy, the Administrator for the Centers for Medicare and Medicaid Services, and other relevant executive department and agency officials, communicate most-favored-nation price targets to pharmaceutical manufacturers to bring prices for American patients in line with comparably developed nations.
  2. If, following the action described in subsection (a) of this section, significant progress towards most-favored-nation pricing for American patients is not delivered, to the extent consistent with law:
    1. the Secretary shall propose a rulemaking plan to impose most-favored-nation pricing; 
    2. the Secretary shall consider certification to the Congress that importation under section 804(j) of the Federal Food, Drug, and Cosmetic Act (FDCA) will pose no additional risk to the public’s health and safety and result in a significant reduction in the cost of prescription drugs to the American consumer; and if the Secretary so certifies, then the Commissioner of Food and Drugs shall take action under section 804(j)(2)(B) of the FDCA to describe circumstances under which waivers will be consistently granted to import prescription drugs on a case-by-case basis from developed nations with low-cost prescription drugs;  
    3. the Attorney General and the Chairman of the Federal Trade Commission shall, to the extent consistent with law, undertake enforcement action against any anti-competitive practices identified in the report issued under EO 14273 - Lowering Drug Prices by Once Again Putting Americans First, including through use of sections 1 and 2 of the Sherman Antitrust Act and section 5 of the Federal Trade Commission Act, as appropriate;
    4. the Secretary of Commerce, and the heads of other relevant agencies as necessary, shall review and consider all necessary action regarding the export of pharmaceutical drugs or precursor material impacting global price discrimination;
    5. the Commissioner of Food and Drugs shall review and potentially modify or revoke approvals granted for drugs, for those drugs that maybe be unsafe, ineffective, or improperly marketed; and
    6.  the heads of agencies shall take all action available, in coordination with the Assistant to the President for Domestic Policy, to address price discrimination.

Additional Documentation

Share This Insight

Related Content

Trump Executive Order Tracker

The significant number of executive orders published by the Trump Administration cut across dozens of industries and areas of law. This searchable tool breaks down the orders and their impacts on specific industries and with in-depth analysis of specific orders.

Previous Entries

Trump Executive Order Tracker

October 15, 2025

Imposes a government-wide freeze on civilian hiring across all executive departments and agencies, except for positions tied to national security, immigration enforcement, and public safety. Requires agencies to establish Strategic Hiring Committees, submit Annual Staffing Plans and quarterly updates to the Office of Personnel Management (OPM) and the Office of Management and Budget (OMB), and align all hiring with the administration's priorities under the Merit Hiring Plan.

...

Read More

Trump Executive Order Tracker

October 15, 2025

Directs the Secretary of Defense to use any available Fiscal Year 2025 funds to continue paying active duty and reserve military personnel during the ongoing lapse in appropriations.

...

Read More

Trump Executive Order Tracker

October 6, 2025

Approves the Alaska Industrial Development and Export Authority’s (AIDEA) appeal under the Alaska National Interest Lands Conservation Act (ANILCA) and reinstates federal authorizations for the 211-mile Ambler Road Project, reversing the Bureau of Land Management’s (BLM) 2024 denial. Directs all relevant federal agencies to promptly reissue permits within 30 days to allow construction and operation of the road connecting the Dalton Highway to the Ambler Mining District.

...

Read More

Trump Executive Order Tracker

August 1, 2025

Directs the Secretary of Defense to federally mobilize at least 300 members of the Illinois National Guard to protect federal personnel, property, and law enforcement operations in response to escalating violence and obstruction in Illinois, especially in Chicago. 
 
This mobilization is effective immediately for up to 60 days, or otherwise determined by the Secretary. 

...

Read More

Trump Executive Order Tracker

September 30, 2025

This order directs the MAHA Commission, in coordination with the Secretary of HHS, the Assistant to the President for Science and Technology (APST), and the Special Advisor for AI and Crypto to develop innovative ways to utilize advanced technologies such as AI to unlock improved diagnoses, treatments, cures, and prevention strategies for pediatric cancer. The initial focus will be to identify opportunities to accelerate the progress of AI-driven solutions at the Childhood Cancer Data Initiative (CCDI) and fund research projects at National Cancer Institute-Designated Cancer Centers that utilize and incorporate AI in their research and analysis.
 
The order calls for increased investment and engagement in pediatric cancer care and research from both the public and private sector. The order requires that the Secretary of HHS and the ASPT ensure that AI innovation is integrated into current work on interoperability.

...

Read More

Trump Executive Order Tracker

September 29, 2025

Imposes tariffs under Section 232 of the Trade Expansion Act on imports of timber, lumber, and wood products to address threats to U.S. national security. Establishes duty rates of 10% on softwood lumber, 25% (rising to 30% on January 1, 2026) on upholstered wooden products, and 25% (rising to 50% on January 1, 2026) on kitchen cabinets and vanities, with capped rates of 10% for the United Kingdom and 15% for the European Union and Japan. Directs the Secretary of Commerce and U.S. Trade Representative to monitor imports, pursue negotiations with foreign partners, and expand tariffs or impose specific, compound, or mixed duties in cases of undervaluation. Authorizes regulatory actions by Commerce, Homeland Security, and Customs to implement these provisions starting October 14, 2025.

...

Read More

Trump Executive Order Tracker

September 29, 2025

Defines any armed attack on Qatar as a threat to the U.S.. Directs the Secretary of War and State Director of National Intelligence to create joint contingency plans with Qatar to respond to threats including diplomatic, economic, or military measures.

...

Read More

Trump Executive Order Tracker

September 29, 2025

Renews 22 federal advisory committees across multiple agencies through September 30, 2027. Assigns responsibility for each committee to the relevant agency head and replaces earlier committee renewal provisions from Executive Order 14109 of September 29, 2023.  

...

Read More

© 2025 Akin Gump Strauss Hauer & Feld LLP. All rights reserved. Attorney advertising. This document is distributed for informational use only; it does not constitute legal advice and should not be used as such. Prior results do not guarantee a similar outcome. Akin is the practicing name of Akin Gump LLP, a New York limited liability partnership authorized and regulated by the Solicitors Regulation Authority under number 267321. A list of the partners is available for inspection at Eighth Floor, Ten Bishops Square, London E1 6EG. For more information about Akin Gump LLP, Akin Gump Strauss Hauer & Feld LLP and other associated entities under which the Akin Gump network operates worldwide, please see our Legal Notices page.